Glasgow prop Ryan Grant will win his first cap, while Edinburgh centre Matt Scott will make his first start as he wins a second.
At least this time he will be able to prepare to play in his preferred position, unlike his debut when he was called into the squad at 20 minutes' notice, and then came off the bench to play at wing for the first time in his career.
Scott, however, probably realised he had a strong chance of starting every game at inside centre after Graeme Morrison, who filled the berth in the last game, was left at home.
The one-off Test against the Wallabies will be played at Newcastle, in Australia's Hunter Valley, on Tuesday.
Scotland team: Stuart Hogg (Glasgow); Joe Ansbro (Edinburgh), Nick De Luca (Edinburgh), Scott (Edinburgh), Sean Lamont (Scarlets); Greig Laidlaw (Edinburgh), Mike Blair (Edinburgh), Grant (Glasgow), Ross Ford (C) (Glasgow), Euan Murray (Newcastle), Alastair Kellock (Glasgow), Richie Gray (Glasgow), Alasdair Strokosch (Gloucester), Ross Rennie (Edinburgh), John Barclay (Glasgow).