South Africa lock Eben Etzebeth faces up to five months out of the game after being told he needs surgery on a foot injury.
Argentina have made five changes for their closing tour match against Italy on Saturday from the team beaten 40-6 by Wales last weekend.
Argentina coach Daniel Hourcade has made four changes to his starting line-up for Saturday's Millennium Stadium clash against Wales.
Argentina will face Wales at the Millennium Stadium on Saturday (1430 GMT) with four changes from the team beaten by England in their opening tour match.
Argentina have made five changes from the team crushed 54-17 by Australia in the Rugby Championship last month for their opening tour match against England at
Argentina lock Manuel Carizza will join Western Province in South Africa after his country's tour of Europe.
Argentina confirmed Daniel Hourcade in his role as the Pumas coach until the 2015 World Cup.
Argentina prop Juan Figallo has pulled out of Saturday's Rugby Championship match against Australia with a back injury.
Centre Felipe Contepomi will set a Pumas caps record in their closing Rugby Championship match in Rosario.
Australia will hope to prevent a wretched run of form turning into a full-blown crisis when they host Argentina.
Argentina coach Santiago Phelan has made five changes to his line-up ahead of their match against Australia in Perth.
Argentina head coach Santiago Phelan has made five changes for Saturday's Rugby Championship test against Australia in Perth.
Dan Carter returns for New Zealand against Argentina needing to reconfirm his position as the All Blacks' best fly-half.
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