The runaway league leaders are guaranteed to finish in the top two now following their 16th win of the campaign, which was rubber-stamped by five second-half tries.
Shane Jennings' fortuitous early try was cancelled out by Nick De Luca's 11th-minute effort, before scores from Fergus McFadden and Sean Cronin saw Leinster break into an 18-7 interval lead.
Fionn Carr's 43rd-minute try sealed the bonus point but Edinburgh leaked four more touchdowns as this clash of the Heineken Cup semi-finalists turned into a romp.
Edinburgh bore a close resemblance to their European line-up, making five changes to the side that shocked Toulouse last weekend.
The game burst into life with a number of players looking to press their claims for more regular game-time, and the sight of Devin Toner galloping into the Edinburgh 22 delighted the home support.
McFadden watched a penalty attempt flick away off the left post, but covering winger Lee Jones failed to control the difficult bouncing ball and Jennings swept in to ground it for the opening try.
McFadden failed to add the conversion and Edinburgh initiated an immediate response, piling through the middle before Laidlaw's pass sent De Luca over for a well-worked try.
The right-sided conversion was landed by Laidlaw to move the Scots 7-5 ahead, but their lead was a brief one as Leinster hit back with a stunning second touchdown.
Countering from deep, Nacewa sent David Kearney surging down the right wing and his inside pass was perfectly timed for McFadden to gather and complete a 40-metre dash to the corner.
But the centre's place-kicking woes continued with a missed conversion and a penalty attempt that went wide at the midpoint of the half.
Edinburgh defended well until Kyle Traynor infringed at a 29th-minute scrum and McFadden was back on target from the resulting kick, splitting the posts from the left.
Laidlaw missed a long range effort and the hosts, retaining possession well, added a third unconverted try when hooker Cronin charged on to Isaac Boss' pass to score from close range.
Into the second half, Edinburgh conceded an early try as Ian Madigan's clever kick to the left was gobbled up by Carr and the conversion was supplied by Nacewa.
Two penalties from Laidlaw kept Michael Bradley's men in touch at 25-13 down, however the hosts really bossed the final quarter.
A Nacewa penalty put 15 points between the sides and then the full-back burst on to a Boss pass to grab try number five which he converted himself.
A powerful lineout maul saw replacement Leo Auva'a crash over for the sixth, and a scintillating length of the field break, sparked by man-of-the-match Madigan, put another reserve, Brendan Macken, over in the same right corner.
The icing on the cake for Joe Schmidt's charges was a last-minute try for giant lock Toner, who darted through a gap and muscled over past the final two defenders.
Benetton Treviso secured a victory on Welsh soil as they beat Newport Gwent Dragons 33-32 for the first time at Rodney Parade since 2007 in a match which turned white hot in the last 25 minutes.
Treviso came from behind, with tries from flanker Alessandro Zanni, full-back Luke McLean, outside-half Kris Burton and centre Alberto Sgarbi, with Burton kicking 13 further points to add a bonus point to their tally.
It was a reasonable game in the first half but became a thriller towards the end. The Dragons got two bonus points as they finished one point adrift of their opponents and also scored four tries, with wing Aled Brew getting two and others coming from number eight Toby Faletau and centre Adam Hughes.