Italy coach Jacques Brunel has called three uncapped players into his 32-man squad for the November test matches.
Exeter Chiefs bounced back to winning ways at Sandy Park as they overcame London Wasps 30-26 to send the visitors to their ninth successive defeat.
Italy will make a number of changes to their squad ahead of their match against Scotland, selecting two new caps.
Italy restored Martin Castrogiovanni, Marco Bergamasco and flyhalf Luciano Orquera to the starting line-up to play Samoa.
Alberto Di Bernardo is set to make his Test debut against South Africa in Durban on Saturday.
Exeter boss Rob Baxter believes his player are in the mood to make a final push towards achieving Heineken Cup qualification on Sunday.
Leicester are the most successful club in English rugby union history when it comes to winning league titles - but hooker Tom Youngs believes it is "too long"
Brian O'Driscoll starts in perhaps his final Six Nations match against Italy while Jonathan Sexton is out with a new injury.
Openside flanker Simone Favaro has returned to the starting line-up in one of three changes for Italy's final Six Nations championship match against Ireland.
Worcester recorded their first win since Christmas while Bath edged a bad-tempered thriller at The Rec.
Wasps' transformation from Aviva Premiership relegation candidates to title play-off challengers could be underlined at Worcester on Friday night.
Leicester prop Martin Castrogiovanni will captain Italy in their Six Nations championship match against Wales at the Stadio Olimpico.
Wasps maintained their unbeaten home record in the Aviva Premiership with a 33-29 victory over Gloucester.
Wasps captain Hugo Southwell has billed Sunday's Aviva Premiership clash against Gloucester as a "massive" game for both clubs.
European Challenge Cup
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