Sam Tomkins sparked the rout, the England international opening the scoring as early as the second minute against a depleted Hull side.
Josh Charnley ran in a hat-trick to go with his six goals as Hull, missing several players through injury, were blown away.
Gareth Hock, Liam Farrell, Michael McIlorum and Sam Powell also scored for Wigan while all Hull could muster was a try in each half from Tom Lineham and Brett Seymour.
Wigan coach Shaun Wane said: "There were times when we could have attacked a bit better and our defence was a bit sloppy in the first half but overall I'm very happy.
"We were without both our halves but credit must go to John Winder, our head of youth, because we had 14 there who have come through the ranks. That's what made the victory more special for me.
"It was really pleasing to see Sam Powell coming back from a broken leg and playing the way he did. He's a really good kid and works hard at his game. We've some great kids in Wigan and he's a good example."