Backing up from Monday night's upset win over Wests Tigers, the Knights scored three tries early in the second half to put the Eels away - their run without consecutive wins stretching to just less than two years.
Having been appointed as the Eels' new director of coaching just days ago, Chris Anderson had an early glimpse of just how much work he had before him as he sat alongside under-pressure coach Stephen Kearney - Parramatta returning to their bad old ways after last week's comeback win over Penrith.
Halfback Chris Sandow showed signs of life in the first half as he set up a Matt Keating try with a clever run in which he beat four defenders, while he was denied a 40-20 only by an athletic save from rookie fullback Kevin Naiqama.
Having gone to the break locked up at 6-6 following James McManus' fifth-minute try, the Knights blew the Eels away with three tries in the space of 17 minutes after the restart.
First, Jarrod Mullen matched the deeds of Sandow when he beat four in a strong run to score beside the posts before Naiqama raced 90 metres to score against the run of play on 51 minutes to break Parramatta's back.
Akuila Uate completed the run when he scored off the back of a Dane Gagai flick pass, but the dumped NSW winger almost had a repeat of his Origin II nightmare when he allowed a bomb to bounce near his home line which Mullen was forced to clean up.
Parramatta gave their fans some hope of yet another late comeback when Ken Sio scored to reduce the gap to eight points with eight minutes remaining, but they failed to convert half chances over the closing stages.