Rhys Evans ran in four tries as Warrington subdued a feisty London 44-16 in the capital.
Taulima Tautai was in destructive form as Wakefield routed Catalan 56-14 to record their first victory of the First Utility Super League season.
Sam Tomkins and Gareth Widdop enjoyed contrasting fortunes on debut for their new clubs in the first round of the NRL.
St Helens made it four wins out of four to move clear at the top and leave Hull KR still seeking their first win of the season.
Widnes twice came from behind to maintain their perfect start to the new Super League season with a 32-18 win over Salford.
Unbeaten Castleford face the acid test of their improvement with the visit of Super League champions Wigan.
Wigan have announced a partnership with Kingstone Press Championship club Workington.
Samoan heavyweight Mose Masoe is set to make his eagerly-awaited Super League debut for St Helens against Hull KR.
Two men have been arrested over an assault in Greater Manchester on Hull KR centre Sean Gleeson, who may lose an eye.
Leeds have come to the aid of struggling neighbours Bradford by loaning them teenage stand-off Liam Sutcliffe.
Keighley player-coach Paul March has been suspended for four matches for questioning the integrity of a match official.
The Rugby Football League is to respond privately to a threat of legal action from the three directors who quit Bradford.
Wigan skipper Sean O'Loughlin justified his selection with two of his side's nine tries in a 46-24 win over Wakefield.
Hull KR centre Sean Gleeson may lose an eye after he was attacked outside a nightclub.
Sean Long's startling revelation that he contemplated suicide earlier this year has once more brought into sharp focus the subject of mental health.
Warrington withstood a spirited second-half fightback from Hull who almost overturned a 12-point deficit before losing 18-16.