The Yamaha rider, who has a 25-point advantage over world champion Casey Stoner, says he is confident of continuing his run at Assen.
Lorenzo hasn't finished lower than second at the track since his debut in 2008 (where he placed sixth), and won the race in 2010 in his championship-winning season with Yamaha.
"Assen and Brno are the tracks I think I have won at the most," said Lorenzo. "I feel very strong there and we are very focused this season so I'm confident.
"We haven't made so many mistakes and are working well towards the championship title. Our target remains to be on the podium each race and if possible take a win. Assen is good for our bike and it suits my riding style so let's see what happens."
Assen has also proved a happy hunting ground for Lorenzo's team-mate Ben Spies who scored his maiden win in the premier class last year.
"I'm really looking forward to this race," said the American, who has struggled for form so far this season. "I love riding the Assen track and have always had great results here, especially last year! The place of your first grand prix win will always be unique.
"We've had a tough start to the year but have made good steps forward so I'm confident that we can step up and be fighting for the podium this weekend."