Striker Ivan Alonso, who left Toluca due to a heart problem last year saying he was quitting soccer, stunned the Mexican side with the winner for Uruguay's
Spanish dominance at club and international level is drawing favourable comparisons with Pele's Brazil 1970 masters.
Real Madrid climbed back above Barcelona to the top of La Liga when Gonzalo Higuain netted a late winner in a 1-0 win at Sporting Gijon.
Real Madrid cancelled their pre-match news conference before Sunday's game at Sporting Gijon to try to defuse a row between the two coaches.
Real Madrid coach Jose Mourinho has been given a two-match ban after being sent off in the Copa del Rey during the week.
Third-placed Villarreal should provide Barcelona with one of their toughest tests in La Liga when they visit the Camp Nou on Saturday.
Copa del Rey fourth-round results: Real Madrid 5-1 Murcia, Real Zaragoza 1-2 Real Betis, Almeria 2-1 Real Sociedad
Any eyebrows raised when Real Madrid coach Jose Mourinho signed compatriot Ricardo Carvalho from Chelsea have now been put back into place.
Athletic Bilbao denied Alcorcon another Copa del Rey shock with a 1-0 win in the first leg of their last-32 tie on Thursday.
Racing Santander suffered a humbling 2-0 first-leg defeat at second division Cordoba in the last 32 of Spain's Copa del Rey.
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