Genoa needed only a point to confirm their Serie A status and enjoyed a 2-0 home win over Palermo.
Lecce's result was therefore immaterial, but they ended a disappointing season on a low note when losing 1-0 at Chievo.
Kamil Vacek scored the winner after 78 minutes as Lecce returned to Serie B for the first time since 2008.
The gloom surrounding the club only deepened on 81 minutes when Morris Carrozzieri was dismissed.
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