Reports in the Spanish press suggest that Diego Costa will start against Italy on Wednesday, but a trio of regulars will miss out.
Juan Mata and Fernando Torres look to be major doubts for the World Cup after being left out of Spain's latest squad.
Spain coach Vicente del Bosque has called up Atletico Madrid's Brazil-born forward Diego Costa for the world and European champions' friendly against Italy in
Swansea's Europa League adventure came to an end in Italy as they lost 3-1 to Napoli on Thursday.
Fernando Llorente's second-half equaliser gave 10-man Juventus a hard-fought 1-1 draw at Lazio to go nine points clear at the top.
Napoli's hopes of a first Serie A title in over two decades are hanging by a thread after a draw against Chievo.
Juventus and Napoli will both be looking to bounce back from European heartbreak ahead of this weekend's Serie A fixtures.
The proposed loan of Alvaro Morata to Arsenal is the latest insult in a very one-sided 'special relationship'.
Spain, back at the scene of their 2010 World Cup title triumph, suffered a surprise 1-0 defeat by South Africa.
Nineteen points adrift of Serie A leaders AS Roma and only three clear of the relegation zone, AC Milan head for their Champions League match against Barcelona
Raul Albiol has been forced to withdraw from Spain's squad for their final two World Cup qualifiers with Belarus and Georgia.
Napoli will be without four players including Gonzalo Higuain for Sunday's Serie A match against Livorno.
Vicente del Bosque has recalled Juan Mata for the holders' final two World Cup 2014 Group I qualifiers.
Goran Pandev fires Napoli to the top of Serie A with a 2-0 victory at Genoa, Milan scrape past Sampdoria at home.
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