Lille playmaker Marvin Martin underwent knee surgery on Thursday and will be out of action for four to six weeks.
Valencia condemned Lille to their worst ever Champions League campaign with a 1-0 victory in France in Group F.
Round-up: Lille reached the semi-finals of the Coupe de la Ligue with a 3-0 win over Bastia.
Jordan Ayew scored as Olympique Marseille beat 10-man Lille 1-0 to move level on points with Ligue 1 leaders Paris St Germain.
Nolan Roux scored deep into extra-time to give Lille a 1-0 home win against Toulouse and a place in the quarter-finals of the Coupe de la Ligue.
Marseille's perfect start has not yet banished the "ghosts" which haunted their dreadful campaign last term, warned left-back Jeremy Morel.
Belarusian club BATE Borisov recorded their first Champions League victory with a 3-1 win against Lille in France.
With a place in the Champions League assured, Lille switch their focus to domestic action as they take on big spending PSG.
Lille's stadium opening party fell flat on Friday when they were held to a 1-1 draw at home by Nancy despite dominating the Ligue 1 tussle.
Few doubt that Paris St Germain's extravagant spending will land them the Ligue 1 title this season, possibly with several games to spare.
Former Chelsea forward Salomon Kalou has joined Lille on a free transfer after his release by the champions of Europe.
Lille have signed France playmaker Marvin Martin on a five-year contract from Ligue 1 rivals Sochaux.
Player ratings from the opening game of England's Euro 2012 campaign against France in Donetsk.
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