Smith has been in the treatment room nursing a groin injury of late but has enjoyed a solid week of training and will replace Hakan Duyan among the substitutes at Priestfield.
Defender Danny O'Donnell and striker Nathan Elder remain long-term absentees with respective groin and knee injuries.
Winger Lionel Ainsworth and midfielder Mark Wright made their returns in last weekend`s 1-0 win over Rotherham and are again likely to start against the Gills, who meet Shrewsbury for the first time since winning 1-0 in the League Two play-off final at the end of the 2008/09 season.
However, it is a different story so far this term, with Town unbeaten in the league and Gillingham still looking for their first victory.
Dennis Oli and Curtis Weston could return to the Gillingham squad for the home clash with Shrewsbury.
Weston has been sidelined with a thigh problem but came through a reserve team game against Brentford in midweek and could be in line to feature.
Striker Oli scored twice for the second string after recovering from a hamstring problem and may also be back in the squad.
Stanley Aborah will not feature at the weekend as he is still short of match fitness but goalkeeper Alan Julian is expected to be on the bench once again despite having a slight fracture of his hand.
Winger Andy Barcham is still not available due to an ankle problem while Garry Richards and Simon King are long-term absentees.