Manager Karl Robinson did not name the players who could miss the game but there are known to be several nursing knocks following a bruising encounter against Sheffield Wednesday last weekend.
The Milton Keynes club have sent a dossier of video evidence to the Football Association in an effort to highlight what Robinson labelled `horrific` tackles made on his players at Hillsborough.
Stephen Gleeson and Darren Potter are likely to be doubts after they were involved in challenges which, Robinson claimed, threatened their careers.
One player certain to be absent is Jabo Ibehre after he was sent off against the Owls. The striker will serve a one-match suspension.
Scotland international Gary Naysmith is hoping to return to Huddersfield's squad for the trip to Milton Keynes.
The 32-year-old left-back missed the midweek win at Sheffield United due to an unspecified knock, but is back in contention as the Terriers bid to extend their unbeaten league run to 34 matches.
Clark is not expected to make too many, if any, changes after his side turned in arguably their best display of the season in the 3-0 at Bramall Lane on Tuesday night.
Striker Lee Novak's double took his goal tally for the season to seven and he can expect to lead the line again, with Jordan Rhodes pushing for a recall along with winger Gary Roberts, midfielder Anton Robinson and skipper Peter Clarke, who has been unable to force his way back into the side following a back injury.