Benoit Cheyrou has been ruled out of Saturday's Ligue 1 home game against Bastia on Saturday, the club said on Thursday.
Andre-Pierre Gignac struck the only goal for the second game in a row as second-placed Marseille beat Bordeaux 1-0.
David Beckham made a winning start to his career with Paris Saint-Germain as Carlo Ancelotti’s men beat Olympique Marseille 2-0 at the Parc des Princes.
Benoit Cheyrou and Morgan Amalfitano have both been ruled out of Marseille's league and French Cup games at PSG.
Lyon's decision put their faith in youth has paid dividends as they head into their derby against arch-rivals St Etienne.
Jordan Ayew scored as Olympique Marseille beat 10-man Lille 1-0 to move level on points with Ligue 1 leaders Paris St Germain.
Paris St Germain's domestic dominance continued when they qualified for the Coupe de la Ligue quarter-finals by knocking out holders Marseille 2-0.
Marseille retained their Ligue 1 top spot with a 2-2 home draw with second-placed Paris St Germain.
Reims were sunk by a late Benoit Cheyrou goal as they lost 1-0 at home to Marseille on their top-flight return after a 33-year absence.
Champions Lille must be especially wary of the attacking threat posed by Jeremy Menez, Javier Pastore and Nene when they play PSG.
An extra-time goal by Brazilian Brandao earned Marseille a third successive French League Cup trophy with a 1-0 victory over Lyon.
Montpellier stayed firmly on track for their first Ligue 1 title with a 3-1 win at slumping Marseille.
Bayern Munich progressed to the semi-finals of the Champions League with a convincing 2-0 quarter-final second-leg win over Marseille.
Round-up: Lille missed an opportunity to reduce the gap with the Ligue 1 leaders when they conceded a last-gasp goal at 10-man Stade Rennes.
Marseille and Lyon lost further ground on the Ligue 1 pacesetters when the hosts blew a two-goal lead in a 2-2 draw at the Stade Velodrome.
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