Crewe manager Steve Davis is convinced his business in the loan market can help the club emerge safely from the threat of relegation.
Chuks Aneke and Mesca both struck in the second half to lift Crewe out of the bottom four.
Carlisle assistant David Irons heaped praise on David Amoo after his quick-fire double consigned 10-man Peterborough to a 2-1 loss.
Peterborough manager Darren Ferguson blasted the general standard of officiating after his 10-man side lost 2-1 in a feisty contest at Carlisle.
Two goals in little over a minute from David Amoo enabled Carlisle to come from behind and win 2-1 against 10-man Peterborough.
Preston got back to winning form at Brunton Park with Josh Brownhill's strike just before half-time earning them a gritty 1-0 win over Carlisle.
Fine goals from Romaine Sawyers and Milan Lalkovic handed Walsall a deserved 2-0 win over a Carlisle side who missed a penalty then had a man sent off three
Carlisle have extended the loan stay of Manchester United goalkeeper Ben Amos until the new year.
Carlisle's on-loan trio Max Ehmer, Ben Amos and Josh Morris will all return to contention for the home game with Tranmere.
Carlisle will be without three loan players against Brentford as Max Ehmer, Ben Amos and Josh Morris have been refused permission to play in the FA Cup.
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