AFPThe French rider edged out compatriot and team-mate Arnaud Demare and Dutchman Tom Veelers of Argos-Shimano.
Bouhanni crossed the line after 4:19:27 to take the title won by Roy Curvers of Skil-Shimano last year.
It was the 65th edition of the single-day race in West Flanders, a 1.1 event on the UCI Europe Tour.
Race result - top 10:
1 Nacer Bouhanni (Fra) FDJ-Big Mat
2 Arnaud Demare (Fra) FDJ-Big Mat
3 Tom Veelers (Ned) Argos-Shimano
4 Kenny De Haes (Bel) Lotto Belisol Team
5 Kenny Robert Van Hummel (Ned) Vacansoleil-Dcm Pro Cycling Team
6 Adrien Petit (Fra) Cofidis, Le Credit En Ligne
7 Kristof Goddaert (Bel) Belgium
8 Michael Van Staeyen (Bel) Topsport Vlaanderen - Mercator
9 Klaas Lodewyck (Bel) Belgium
10 Kevin Ista (Bel) Accent Jobs - Willems Veranda's
