Collazo, 32, from Brooklyn, NY, could box Khan on the undercard of Floyd Mayweather’s clash with Marcos Maidana on May 3.
"I definitely proved that I should be considered part of the top tier of the welterweight division when I beat Victor Ortiz," he said.
"Another name that has been a part of that conversation for a long time is Amir Khan and I know that a fight against him would be huge for both of us and huge for the fans.
"Khan wants a shot at Floyd Mayweather and so do I. It could be a sort of welterweight playoff that would get the boxing world talking. And mark my words, I will knock Khan out like I did against Ortiz."
Collazo captured the WBA welterweight title back in 2005, which he lost to Ricky Hatton a year later. Other losses have come to ‘Sugar’ Shane Mosley in 2007 and Andre Berto in 2009 while challenging for the WBC version.
By knocking out Victor Ortiz in the second round in January, Collazo recorded perhaps his career best win, and is unbeaten in his last four.
Khan hasn’t fought since April last year, a points win over Mexican Julio Diaz in which Khan saw the canvas in the fourth round. His trainer Virgil Hunter expressed his disappointment recently that a fight against Mayweather didn’t materialise, but is highly confident of it taking place in the future.
Hunter said: "It was a disappointment of course because you'd like to have people stay true to their word and unfortunately in this particular incident they weren't true to their word," Hunter said.
"But because Amir has handled it quite well I think it will turn out to be a blessing in disguise so we move forward.
"But it's definitely going to happen. I am very confident through the circle of people that I speak to. The people who are speaking on that matter are very true to their word so yes that fight will happen."