Hill tweaked his ankle early in the June 9 match against Richmond, but battled on through the pain to play a crucial role in the 12-point win.
However, last week's bye wasn't enough for Hill to sufficiently recover from the injury, with Dockers coach Ross Lyon confirming the 22-year-old was unlikely to face the Bombers.
Hill's absence comes at a bad time for the Dockers, who also need to find replacements for ruckman Aaron Sandilands (turf toe), defender Zac Dawson (knee) and goalsneak Hayden Ballantyne (suspended).
Kepler Bradley and Zac Clarke will battle it out to replace Sandilands, while Alex Silvagni is set to come in for Dawson.
Lyon said Michael Walters, Jayden Pitt, Nick Lower and Paul Duffield were all in the selection mix for the other two spots, but midfielder Anthony Morabito will spend at least another week in the WAFL building match fitness.
Fremantle sit 11th on the table with a 6-5 record, while the Bombers have compiled an 8-3 record but enter Saturday's clash on the back of two straight losses.