Sanderson refused to name the omitted players before the release of teams later on Thursday.
But he said there would be more changes than just replacing young defender Daniel Talia, who broke his right arm during Adelaide's qualifying loss to Sydney last weekend.
"We'll probably make two or three changes," Sanderson told reporters after Adelaide's light training session at AAMI Stadium.
"We look at what works well against Fremantle but also too what works well for us.
"It's more so getting the structure right for us, we're pretty confident the 22 that we have picked this week just looks really good.
"It's a cut-throat final, the loser goes home, so it's really important we put a 22 out there that we think are going to compete and win us the match."
Sanderson said key forward Kurt Tippett, who had a poor game against the Swans, would definitely play against a Fremantle side buoyed by their elimination final win against Geelong last weekend.
Dockers captain Matthew Pavlich starred with six goals against the Cats and Sanderson said more than one Crow would be given the task of minding the potential game-breaker.
"We'll look at not just one player playing on Pav, there will be different players playing on Pavlich at different times," Sanderson said.
"They have got some weapons up there offensively so if we put all our attention into Pavlich those other guys will hurt us."