The Cats dropped ruckman Dawson Simpson and triple-premiership player David Wojcinski on Friday following last week's six-point loss to the Swans at the SCG.
Geelong have made four changes in total, ruling out forward/midfielder Paul Chapman (groin) and defender Josh Hunt (toe) because of injury.
Teenagers Cam Guthrie, Billie Smedts and George Horlin-Smith come into the side with 20-year-old debutant Murdoch.
The Glenelg recruit, a 189cm utility with loads of pace, was plucked from the VFL after just one game back from a broken finger.
The Cats said on their website on Friday that Murdoch had been likened to 1998 club champion and 288-game veteran Riccardi because of his booming left foot and speed.
Murdoch recorded the quickest time at last year's Draft Combine of 2.76 seconds for the 20-metre sprint.